'What we can assume based on our current understanding, and can be valid for all types of aneurysm, is that irregular time-dependent flow patterns can come into existence, which modifies the structure of the vessel wall, initiating and eventually growing an aneurysm. In the process, this local irregular flow mechanically disproportionately stresses the endothelium. The endothelium – in effect – translates this mechanical signal into a biochemical one, which promotes a set of biological processes, to form an aneurysm.
The study of aneurysm formation mechanisms is a bit closer to what we can call basic research. Its clinical significance is, probably, that the doctors can have more in-depth knowledge with such information, about the natural course of the illness. Yet, our research findings can have practical impacts as well.' More
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